Jiajia Luo, Yuhuan Xiang

(College of Life Sciences, Hunan University of Science and Technology)

Abstract：

The human gut has a large and complex symbiotic microbiota, and the stable state of its community affects the body's energy absorption, substance metabolism, and immune regulation functions. The imbalance of intestinal microecology has a causal relationship with the occurrence and development of obesity, depression, diabetes and related metabolic diseases, but the specific mechanism is still unclear. There is a complete metabolic system and continuous rich metabolic exchange between the gut microbiota and the host, jointly responding to environmental changes and affecting host health. Dietary regulation can intervene in the composition and quantity of host microbiota, improving human metabolism. This article conducts personalized, precise, and targeted interventions in the field of gut microbiota from the perspectives of dietary fiber, probiotics, fecal microbiota transplantation, and epigenetics^[1]. It deeply reveals the composition and variation patterns of multi omics combined applications in the field of microbiology. Future research hotspots should focus on the long-term impact and safety of intestinal intervention methods, control and eliminate possible variations in the process, develop precise and efficient intervention pathways, and provide medical evidence for chronic disease prevention and health promotion.

Key Words：

gut microbiota; nutrition and health; research progress