Youlu Pan, Shenxin Zeng

(College of Resources and Environmental Engineering, Yunnan Energy Vocational and Technical College)

Abstract：

Surface enhanced Raman spectroscopy (SERS) has been widely used in recent years for the characterization of materials and structures, analysis of artworks and cultural relics, as well as analysis and detection of small molecules, proteins, DNA and other substances. This is because the technology has many advantages, such as strong Raman peaks, high sensitivity, good specificity, and requires very small sample sizes for detection, enabling non-destructive analysis and minimal background interference. However, the detection sensitivity of Raman sensors still needs to be further improved. This article summarizes the development process and mechanism of surface enhanced Raman spectroscopy technology, as well as signal amplification strategies and biosensors based on DNA nanostructures, providing ideas for future biosensors based on surface enhanced Raman spectroscopy technology.

Key Words：

mechanism; signal amplification strategy; DNA nanostructure; biosensors