Tianqi Chen, Xiaobei Liu

(1.Hubei University of Arts and Sciences Affiliated Hospital Xiangyang Central Hospital; 2.The First Clinical Medical College of Mudanjiang Medical College)

Abstract：

Objective: To observe the effects of different hyperbaric oxygen treatment time windows on the prognosis and neurological function of acute cerebral infarction. Method: 160 patients with acute cerebral infarction admitted to Xiangyang Central Hospital in Hubei Province were randomly divided into four groups, each with 40 cases, using a random number table method. According to the 2017 guidelines for the treatment of cerebral infarction, the control group received routine treatment for acute cerebral infarction; On the basis of the control group, patients in Group A received hyperbaric oxygen therapy within 48 hours of onset; Group B patients receive hyperbaric oxygen therapy within 3-6 days of onset; Group C patients receive hyperbaric oxygen therapy within 7-12 days of onset. Observe the efficacy, recurrence, and neurological function recovery of four groups of patients after treatment. Result: There was no statistically significant difference in the National Institutes of Health Stroke Scale (NIHSS) and Barthel Index (BI) scores among the four groups before treatment (P>0.05). There were statistically significant differences in NIHSS and BI scores between 14 and 30 days after treatment and before treatment (F=16.352, 27.261, 11.899, 28.326, P<0.05). At 14 and 30 days after treatment, the NIHSS score in Group A decreased compared to the control group, Group B, and Group C, while the BI score increased compared to the control group, Group B, and Group C, with statistical significance (P<0.05). There was no statistically significant difference in NIHSS and BI scores between Group C and the control group after treatment (P>0.05). After 30 days of treatment, the total effective rate of Group A was higher than that of the control group and Group C, and the difference was statistically significant(X2 =6.135, P< 0.05). The one-year recurrence rate of Group A and Group B is lower than that of Group C and the control group, and the difference is statistically significant(X2 =8.331, P<0.05). There was no statistically significant difference in adverse reactions among the four groups (P>0.05). Conclusion: Patients with acute cerebral infarction who receive hyperbaric oxygen therapy within 48 hours can improve neurological function and reduce the recurrence rate. The efficacy of receiving hyperbaric oxygen therapy within 7-12 days of onset is equivalent to that of not receiving hyperbaric oxygen therapy.

Key Words：

acute cerebral infarction; neurological function; hyperbaric oxygen; recrudescence