Qian Huang, Chulin Yu

(Youjiang University of Ethnic Medicine)

Abstract：

Acute coronary syndrome (ACS) is one of the leading causes of death in patients with chronic kidney disease (CKD), especially uremia. The main cause of ACS is closely related to atherosclerosis and intra arterial thrombosis caused by vascular endothelial dysfunction. Indolephenol sulfate (IS) is a metabolic product of tryptophan under the action of intestinal bacteria. In CKD patients, especially those with uremia, IS cannot be effectively excreted from the body, causing accumulation in the body and leading to endothelial dysfunction from multiple aspects, playing an important role in the occurrence and development of ACS. This article mainly reviews the latest progress in the mechanisms of endothelial injury and thrombosis caused by IS in CKD patients at home and abroad in recent years, and summarizes the new measures to alleviate ACS caused by IS in CKD patients, providing assistance for the prevention and treatment of cardiovascular events in CKD patients.

Key Words：

chronic kidney disease; endothelial dysfunction; endothelial cells; acute coronary syndrome; indolephenol sulfate