MA Hua, SI Yu

(The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China)

Abstract：

Female reproductive disorder is a clinical syndrome characterized by fertility disorder, which can cause infertility, recurrent abortion, abnormal in vitro embryonic development, etc, seriously reduce the quality of life of patients, and bring greater economic burden to the society. As a second messenger, mitochondria are involved in many key biological processes. Abnormal function of mitochondria can induce cell dysfunction and cause a series of reproductive disorders. Recent studies have found that mitochondrial quality control (MQC) imbalance, characterized by abnormalities in mitochondrial biogenesis, fusion and fission, autophagy and calcium regulation, plays an important role in female reproductive disorders. This study reviewed the progress of the role of MQC in female reproductive disorders, and summarized the traditional Chinese medicine treatment targeting MQC in the treatment of reproductive disorders, in order to provide reference and ideas for the study of treatment strategies for reproductive disorders.

Key Words：

mitochondrial quality control; female reproductive disorder; traditional Chinese medicine; research progress