Jingcheng Yu, Luyi Zhang

(School of Biomedical Sciences, Shandong First Medical University)

Abstract：

Concurrent radiotherapy and chemotherapy is the main treatment for patients with rectal cancer and cervical cancer during locally advanced and middle to advanced. The pelvis is the largest proportion of hematopoietic bone marrow in the whole body, and it is an unavoidable area of radiotherapy for pelvic tumor patients. Concurrent radiotherapy and chemotherapy can improve the curative effect, but also increase the incidence of hematologic toxicity. Once severe bone marrow suppression occurs in concurrent radiotherapy and chemotherapy, the treatment will be interrupted, the time of treatment will be prolonged, and ultimately affect the curative effect. Bone marrow suppression risk identification are the important issues that need to be solved in the tumor radiation and chemotherapy treatment. This paper reviewed the research status of the correlation between radiotherapy and chemotherapy and bone marrow suppression in pelvic tumors at home and abroad from the aspects of radiotherapy technology, radiotherapy dosimetry parameters, chemotherapy regimens and so on . We aimed to provide reference for the construction of a prediction model of bone marrow suppression in our country, in order to identify high-risk groups early, formulate prevention and treatment.

Key Words：

pelvic tumor; radiotherapy and chemotherapy; bone marrow suppression