Rui Ma, Shangru Li

(Qinghai University School of Clinical Medicine)

Abstract：

CRISPR/Cas9, as a third-generation gene editing technology, can modify the genetic information of organisms at the molecular level and is widely used in gene function research, model construction, and gene therapy. It has the advantages of high editing efficiency, simple operation, low cost, and diverse recognition sites. Hereditary heart disease refers to the heart disease that is inherited to the next generation through gene dominance. It has always been the main cause of incidence rate and mortality related to human diseases. This article provides a detailed explanation of the development history, composition principles, and modeling and treatment of genetic heart disease using CRISPR/Cas9 technology, and predicts the future prospects of CRISPR/Cas9 technology.

Key Words：

CRISPR/Cas9; gene editing; hereditary heart disease