Huijie Zhou, Mingjun Zhu

(The Second Clinical School of Anhui Medical University)

Abstract：

Young female with prosthetic heart valves are associated with an increased risk of maternal or fetal/neonatal adverse events during perinatal period ,particularly pregnant women with mechanical valves are associated with a higher risk of adverse events ,primarily due to anticoagulant therapy and the inherent thrombogenic nature of mechanical valves. Young female with bioprosthetic valves will face reoperation due to bioprosthetic valve deterioration and its limited long⁃term durability , the choice for bioprosthetic heart valves in these young female is not indisputable. In this article ,we reviewed the anticoagulant management for pregnant women after mechanical valve replacement , various adverse events during pregnancy , new generation prosthetic valves , and new valve replacement techniques ,which provides a theoretical basis for the choice of valve replacement for young female with pregnancy wish.

Key Words：

prosthetic heart valve; gravida; anticoagulant drug; valvular heart disease