Wentao Jiao, Jiayue Hu

(Clinical Medicine College of Kunming University of Science and Technology)

Abstract：

Coronary heart disease is mainly caused by coronary atherosclerotic lesions that lead to stenosis or even blockage of the lumen, resulting in serious consequences such as myocardial ischemia, hypoxia and even necrosis. Extracellular matrix remodeling plays an important role in the occurrence and development of coronary atherosclerosis, especially in the process of plaque rupture and repair. The ADAMTS family, which contains platelet binding protein motifs, is a newly discovered zinc dependent metalloprotease family. Studies have shown that its members are involved in extracellular matrix remodeling, regulating vascular wall cell proliferation and migration, angiogenesis, and thrombosis, and are closely related to coronary heart disease, especially plaque stability. This article reviews the research progress on the roles and mechanisms of major members of the ADAMTS family in coronary heart disease, in order to provide new ideas for the prevention and treatment of coronary heart disease.

Key Words：

coronary heart disease; depolymerized protein like metalloproteinases containing platelet binding protein motifs; metalloproteinase; extracellular matrix; vulnerable plaque