Liu Xiaoxiao

Anhui Medical University

Abstract：

Coronary artery disease represents a major cardiovascular disorder that threatens the health of elderly individuals, and dual antiplatelet therapy serves as a core intervention for reducing ischemic events in this population. The rational determination of dual antiplatelet therapy duration is critical for balancing thromboprophylactic efficacy and safety profiles. This study focuses on elderly patients with coronary artery disease, aiming to investigate the association between different durations of dual antiplatelet therapy and bleeding risk, to identify optimal therapeutic patterns that favor clinical safety, and to provide evidence‑based references for refining individualized antiplatelet strategies in elderly cohorts. The findings support the optimization of clinical decision‑making and help improve the quality of antithrombotic care for elderly patients with coronary artery disease. The study adopts a rigorous observational design, collects comprehensive clinical data from multiple clinical centers, and uses standardized statistical methods to analyze the relationship between therapy duration and bleeding outcomes. Through systematic analysis of baseline characteristics, bleeding event distribution, and related influencing factors, the study clarifies the potential association between different dual antiplatelet therapy durations and bleeding risk in elderly patients, providing practical guidance for clinical practice. The research process strictly abides by ethical norms and clinical research standards, ensuring the reliability and authenticity of the results, which can further promote the standardization of antiplatelet therapy in elderly patients with coronary artery disease and improve the level of clinical safety management.

Key Words：

dual antiplatelet therapy; elderly patients; bleeding risk