Richeng Yang, Jianhua Qian

(1. Harbin Medical University; 2. Haiyuan College of Kunming Medical University.)

Abstract：

The incidence rate of breast cancer is very high. Some patients were diagnosed as stage IV patients at the first diagnosis and had distant metastasis. Bone, lung and liver are the common metastatic sites of breast cancer. Although brain is the least common metastatic site of breast cancer, the incidence of brain metastasis in newly diagnosed breast cancer patients is increasing year by year. After brain metastasis, the disease develops rapidly, and because of the existence of blood cerebrospinal fluid barrier, it is difficult for drugs to reach the focus, and the curative effect is poor, leading to poor prognosis of patients with brain metastasis of breast cancer. Previous studies have also explored the clinical characteristics of brain metastases from breast cancer and the factors affecting prognosis. Different ages, races, histological grades, T stages, N stages, molecular subtypes, and pathological types are the main factors affecting the occurrence and prognosis of brain metastases from breast cancer. Studies on the characteristics, mechanisms, and treatment plans of brain metastases from breast cancer have also been reported at home and abroad. This article reviews the clinical characteristics, pathogenesis and treatment progress of brain metastases from breast cancer, aiming to provide some ideas and basis for clinical diagnosis and treatment and drug research of brain metastases from breast cancer.

Key Words：

breast cancer; brain metastasis; stereotactic radiation therapy