Yu Kangcheng

Anhui University of Chinese Medicine

Abstract：

Metabolic reprogramming is the systematic remodeling of energy and substance metabolism pathways by cells under pathological stimuli. Its core feature is the disruption of normal metabolic homeostasis. By adjusting the activity of key metabolic pathways and altering metabolite distribution, cells meet their survival, proliferation, or stress response demands under pathological conditions. This process is a core driver in the initiation and progression of numerous diseases. In recent years, with the rapid advancement of technologies like metabolomics and genomics, the mechanisms of metabolic reprogramming in major diseases such as cancer, metabolic disorders, and neurodegenerative diseases have been progressively elucidated. Consequently, its regulatory nodes have emerged as potential targets for disease intervention. This review systematically outlines the foundational mechanisms of metabolic reprogramming, including the reprogramming characteristics of key metabolic pathways, regulatory factors, and metabolic differences between normal and diseased cells. It elaborates on the specific roles and molecular mechanisms of metabolic reprogramming in various major diseases. A key focus is summarizing the principles and technical methods for screening disease-related metabolic reprogramming intervention targets, along with strategies for screening and validating targets such as metabolic enzymes and regulatory factors. The specificity and clinical translation potential of these targets are also analyzed. Finally, the current research status, existing challenges, and future directions in the field of metabolic reprogramming are discussed, providing a theoretical basis and new ideas for subsequent research on metabolic interventions and the development of novel therapeutics.

Key Words：

Metabolic reprogramming; Disease mechanism; Intervention target; Metabolic pathway; Target screening; Clinical translation