王淑贞1 王思寒1 王宗晓2 孔 钰3*
1.济宁医学院临床医学院 2.济宁医学院医学影像与检验学院 3.济宁医学院附属医院医学影像科
摘要(Abstract):
自闭症谱系障碍(ASD)是一种高度异质性的神经发育障碍性疾病,其神经机制尚不明确。传统行为学诊断方法存在主观性强、特异性不足等局限,而单模态神经影像研究难以全面捕捉ASD的复杂病理特征。有研究发现ASD的核心神经特征表现为大脑结构与功能连接网络的异常。脑网络影像技术与人工智能(AI)的深度融合将ASD的研究超越单一脑区定位的局限,通过揭示全脑网络连接模式及其动态演化规律,从系统水平分析ASD的神经机制。本文系统综述了脑网络影像学与人工智能(AI)技术在ASD应用中的研究进展,深度剖析了当前研究面临的数据异质性、纵向研究缺乏、多组学融合不足及算法可解释性有限等挑战,探讨未来发展的前沿方向,为推动ASD的精准诊疗提供科学框架。
关键词(KeyWords):
自闭症谱系障碍;脑网络影像;人工智能;机器学习;深度学习
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